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    福瑞沃農大產品
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      福瑞沃農大產品>>粉劑>>恩諾沙星可溶性粉
     
    恩諾沙星 可溶性粉
     
     
    生產許可證:(2013)獸藥生產證字04104號
    GMP證號: (2013)獸藥GMP證字173號
     
    恩諾沙星可溶性粉 使用說明書
     
    【獸藥名稱】                                                   
    通 用 名:恩諾沙星可溶性粉
    商 品 名:瑞沃心肝包治
    英 文 名:Enrofloxacin Soluble Powder
    漢語拼音:Ennuoshaxing Kerongxingfen
    【主要成分】恩諾沙星
    【性    狀】本品為白色或淡黃色粉末。
    【藥理作用】藥效學 本品是動物專用的殺菌性廣譜抗菌藥物。對大腸桿菌、沙門氏菌、克雷伯氏桿菌、布魯氏菌、巴氏桿菌、胸膜肺炎放線桿菌、丹毒桿菌、變形桿菌、黏質沙雷氏菌、化膿性棒狀桿菌、敗血波特氏菌、金黃色葡萄球菌、支原體和衣原體等均有良好作用,對銅綠假單胞菌和鏈球菌的作用較弱,對厭氧菌作用微弱。本品對大多數菌珠的MIC均低于1μg/ml。對敏感菌有明顯的抗菌后效應(PAE)。本品的抗菌機制是作用于細菌細胞的DNA旋轉酶,干擾細菌DNA的復制、轉錄和修復重組,細菌不能正常生長繁殖而死亡。其作用有明顯的濃度依賴性,血藥濃度大于8倍MIC時可發揮最佳治療效果。
    本品適用于牛、豬、禽、犬、貓和水生動物的敏感細菌及支原體所致的消化系統、呼吸系統、泌尿系統及皮膚軟組織的各種感染。主要用于支原體病、巴氏桿菌病、大腸桿菌病、沙門氏菌病和鏈球菌病等。
      藥動學 大多數動物內服本品能很好吸收,犬內服的生物利用度約80%,為環丙沙星的2倍,內服后15分鐘可達峰濃度的50%1小時內達峰值。胃內食物可延遲藥物吸收速率,但不影響吸收數量。內服的生物利用度,綿羊為65%-75%,雞為62.2%-84%,豬和未反芻犢牛為80%-100%,反芻動物低于10%。肌內注射吸收迅速而完全,生物利用度豬為91.9%,奶牛為82,駱駝為92%。在動物體內廣泛分布,能很好進入組織、體液(包括骨骼和前列腺),除了腦脊液的濃度只有血清濃度的6%-10%外,幾乎所有組織的藥物濃度均高于血漿,能在白細胞蓄積達血漿濃度的140倍。表觀分布容積,犬為3-4L/kg、牛為1.5L/kg、綿羊為0.4L/kg。血漿蛋白結合率,犬為27%肝臟代謝主要是脫去7-哌嗪環的乙基生成環丙沙星,其次為氧化及葡萄糖醛酸結合。循環中的10%-40%恩諾沙星在大多數動物包括犬、豬、成年馬、牛、駒、豬、龜、蛇體內被代謝為環丙沙星,但在蜥蜴體內很少代謝為環丙沙星。消除主要通過腎臟(以腎小管分泌和腎小球濾過)排出,15%-50%以原形從尿中排出。半衰期在不同種屬動物和不同給藥途徑有較大差異,靜脈注射本品的半衰期牛為1.7-2.3小時,馬為4.4小時,豬為3.5小時,雞為5.3-10.3小時,犬為2.4小時;肌內注射本品的半衰期奶牛為5.9小時,馬為9.9小時,綿羊為1.5-4.5小時,豬為4.6小時;內服本品的半衰期豬為6.9小時,犬為3.7-5.8小時,貓為6小時,雞為9.1-14.2小時。
    【藥物相互作用】①本品與氨基糖苷類或廣譜青霉素類合用,有協同作用。②Ca2+Mg2+Fe3+Ab3+等重金屬離子可與本品發生螯合,影響吸收。③與茶堿、咖啡因合用時,由于蛋白結合率改變,血漿蛋白結合率降低,血中茶堿、咖啡因的濃度異常升高,甚至出現茶堿中毒癥狀。④本品有抑制肝藥酶作用,可使主要在肝臟中代謝的藥物的清除率降低,血藥濃度升高。
    【作用與用途】用于畜禽細菌性疾病和支原體感染。 (按恩諾沙星片項下編寫)
    【用法與用量】以恩諾沙星計。混飲:每1L水,雞25-75mg一日2次,連用3-5日。
    【不良反應】本品毒性較小,臨床使用安全。其主要不良反應有:①使幼齡動物軟骨發生變性,影響骨骼發育并引起跛行及疼痛。②消化系統的反應有嘔吐、食欲不振、腹瀉等。③皮膚反應有紅斑、瘙癢、蕁麻疹及光敏反應等。④犬、貓偶見過敏反應、共濟失調、癲癇發作。
    【注意事項】產蛋雞禁用。
    【含量規格】10%
    【包裝規格】100g/袋
    【貯    藏】遮光,密封,在干燥處保存。
    【休 藥 期】雞8日,蛋雞產蛋期禁用。
    【執行標準】《獸藥國家標準(化學藥品、中藥卷)第一冊》
    【批準文號】
    【有 效 期】2年
    【生產企業】山西福瑞沃農大生物技術工程有限公司
    生產地址:山西省晉中市榆次區郭家堡鄉王村(晉中農校舊址)
     
     


    版權所有山西瑞象·福瑞沃農大生物公司 Copyright @2008 furuiwo Corp,LTD. 晉ICP備09000294號
    地址:山西省太原市小店區經濟技術開發區大昌南路15號。 郵編:030032 電話:15333644068 技術支持:龍騰偉業  
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